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People who chew or dip tobacco are especially at risk for squamous cell carcinoma inside their mouths because squamous cells make up the mucosa layer (the outermost lining) of tissue on the inside of the mouth, including the lips and cheeks

This effect often happens when you are on your way to quitting tobacco or dont consume chewing tobacco as often as you would often do

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WHAT IS SMOKELESS TOBACCO

The tobacco leaf itself contains nitrosamines, tar, and other carcinogens that directly contact the mouths soft tissue over extended use

Furthermore, they seem to have the potential to be more predictive of effects in humans since they are derived from biopsied human cells and contain many of the relevant differentiated cell types not found in monolayer cultures